Spike Chunsoft's Danganronpa 2×2, a remake of Danganronpa 2: Goodbye Despair, is set to introduce a new narrative branch titled "Slayhem." This "what if" scenario will present an entirely different set of murder mysteries and potential outcomes for the game's cast of 16 students. The original Danganronpa 2 concluded with five survivors, but "Slayhem" suggests that the group emerging from this new killing game, even if only emotionally scarred, could be markedly different.

The Danganronpa series centers on a group of high school students trapped by the animatronic Monokuma and forced into a killing game. To escape their confinement, students must commit murder and avoid being discovered. Players then take on the role of a protagonist who must solve these murders, leading to the perpetrator's execution by Monokuma. These executions are typically elaborate and ironic, often referencing the victim's unique talent. Danganronpa 2×2 is expected to feature new murders and executions as part of its original storyline.

Given that the Danganronpa 2 cast has a complete narrative arc through their original game and the subsequent Danganronpa 3 anime, the "Slayhem" storyline in 2×2 is anticipated to draw from both sources. This approach will likely subvert and invert the established outcomes of the original game, remixing them into a fresh narrative experience. The "Slayhem" scenario's unique mysteries mean that characters who survived the original "Killing School Trip" might meet different fates, and those who perished could potentially live. The game has been delayed into 2027, providing ample time for speculation on which Ultimates will become killers, victims, or survivors in this reimagined scenario.