Mega Man: Dual Override is a mainline entry in the long-running series, despite its lack of a numerical designation, according to producer Hiroyuki Minamitani. This approach aims to make the game more accessible to players who may have been introduced to the character through other media, such as Super Smash Bros. Ultimate or Fortnite. "We felt that we want the title to be more approachable for that audience, as well," Minamitani stated. The game's narrative is designed to stand alone within the Mega Man canon, allowing new players to jump in without prior knowledge of the series' lore, though it will feature callbacks and references as a celebration of Mega Man's 40th anniversary.

The game introduces a new structure where each robot master stage is segmented into distinct areas, each culminating in a boss fight. This design choice provides players with more frequent "segmented senses of accomplishment," as described by director Shinya Ikuta. This contrasts with the traditional Mega Man formula where challenge progressively increases towards the end of a single, longer stage. The segmented structure also creates opportunities to include both new and returning bosses, further tying into the 40th anniversary theme. During a hands-on preview, the boss Twinkle Girl, an "exuberant performer" who utilizes fireworks, presented a notable challenge with her erratic movements and attacks.

A key new gameplay mechanic is the Dual Override ability. This allows players to build up a meter for limited-time enhanced firepower. The previewer found the option to have it automatically activate at low health particularly effective, providing a "one last shot!" moments without compromising the overall challenge. Maintaining a defensive playstyle is still crucial even when Dual Override is active, as low health persists. The ability to charge weapons for even more powerful shots in this mode was also highlighted, with the option to skip the accompanying cutscene being a welcome addition.

While the previewer expressed enthusiasm for Mega Man: Dual Override, they also noted the long absence of a new mainline Mega Man X game, with the last entry, X8, having released in 2004. Series producer Shingo Izumi acknowledged the importance of the Mega Man X series, stating, "Mega Man X is an important series within the Mega Man brand. We definitely value that series, and if there is a chance, we would always love to consider that." This suggests a potential openness from Capcom to revisiting the Mega Man X sub-series in the future.