The Gene of AI: An Overlooked Sci-Fi Masterpiece Tackling Today's AI Dilemmas

Kyuri Yamada's manga and its 2023 anime adaptation offer a unique, character-driven perspective on artificial intelligence that feels remarkably prescient.

Jun 28, 2026
Culture & Opinion
The Gene of AI: An Overlooked Sci-Fi Masterpiece Tackling Today's AI Dilemmas

Anime has long been a fertile ground for exploring artificial intelligence, from the philosophical inquiries of Ghost in the Shell to the man-machine coexistence explored in Time of Eve and the emotional capacity of AI in Netflix's Pluto. Amidst this rich history, The Gene of AI, a 2015 manga by Kyuri Yamada with a 2023 anime adaptation produced by Madhouse, has emerged as a particularly relevant work for our current moment.

Unlike many AI narratives that focus on dystopian futures or world-ending threats, The Gene of AI presents a more intimate, medical drama-esque approach. The series follows Dr. Hikaru Sudo, a physician who treats humanoids living alongside humans in the near future. His patients present a range of ethical quandaries, from psychological trauma in artificial beings to complex human-artificial relationships. Sudo's practice becomes a moral landscape where every decision risks redefining the very essence of humanity.

The show's patient-procedural format lends itself to an accessible viewing experience. Each episode tackles a distinct moral question without requiring deep immersion into a complex science fiction universe. Themes such as the ethics of altering an AI's emotions or the fundamental nature of love between humans and artificial beings are explored, rarely offering definitive answers.

This narrative restraint was a deliberate choice, as highlighted by editor Ichiro Miyazaki in an interview with Anime Hunch. Miyazaki emphasized that the stories are designed to encourage audiences to form their own conclusions rather than prescribing a single "correct" path. "Instead, the series is designed to invite readers to think for themselves," he stated.

Miyazaki further posited that in an era of readily available AI-generated answers, the process of thinking itself has become paramount. This perspective is notably profound for a series that originated in 2015. The Gene of AI began as a one-shot before its compelling concept convinced publisher Akita Shoten to develop it into a full series. Yamada's background as a journalist covering the IT industry lends an authentic grounding to the narrative, setting it apart from AI fiction that relies heavily on spectacle.

In contrast to contemporary discourse that often frames AI as either a tool for productivity or an existential threat, The Gene of AI narrows the focus to the individual. It explores what happens when artificial beings require compassion rather than mere technological advancement. The series prompts a vital question: in a future where the lines between human and artificial blur completely, will humanity retain its capacity for basic empathy?

The Gene of AI is currently available for streaming on Crunchyroll.

Sources